Immune Defense Summary

Biohacking Air Travel ( Bonus Material)

Here are the body’s biochemical defense systems that modulate the immune system and increase resilience against disease. Consider stimulating and upregulating the following physiological factors:

GLUTATHIONE (THE MASTER ANTIOXIDANT)

  • Glutathione is the body’s main antioxidant defense mechanism produced in the liver
  • It protects against free radicals and helps to eliminate lipid peroxides as well as toxins. This is by far more powerful than antioxidant supplements or vitamins because the body will self-regulate glutathione’s role in the immune system.

NRF2 PATHWAY

  • Nrf2 is one of the main regulators of antioxidants and cell protection. It promotes glutathione, NADPH, thioredoxin and other antioxidant pathways.
  • Regular exercise stimulates the body’s defense mechanisms and strengthens immunity by activating Nrf2.
  • One of the most powerful activators of the NRF2 is sulforaphane which is produced from broccoli seeds. See chart below for other activators.

AUTOPHAGY (THE MAJOR CLEANING SYSTEM OF THE BODY)

  • Cellular self-eating modulates immunity and elimination of pathogens via autophagy
  • The body recognizes damaged cells and recycles them. Autophagy gets triggered in response to stress like infections, starvation, high exertion or certain compounds such as various phytochemicals.
  • You can promote autophagy with foods such as natto, matcha and positive stressors such as calorie restriction, intermittent fasting, regular sauna, exercise and cold exposure

NAD+ (THE KEY ENZYME IN EVERY CELL)

  • Nicotinamide adenine dinucleotide (NAD+) is a major cofactor that partakes in virtually all cellular reactions
  • It promotes energy production and enables cells to work properly
  • NAD+ deficiencies are linked to aging and disease.
  • Low NAD+ is also known to inhibit the body’s immune system and natural defense mechanisms.

URIC ACID

  • Uric acid is the most concentrated antioxidant in the human blood that helps to mitigate oxidative stress, especially at high altitudes and under hypoxia
  • In high amounts it can cause gout and fibromyalgia, but in low concentrations it is actually beneficial
  • You obtain it from purine-rich foods like soy, sea veg & brassica vegetables.

NITRIC OXIDE

  • Nitric oxide (NO) is an important signaling molecule between cells and it has been shown to fight against some viral and bacterial infections
  • Supplementation with NO boosters (for example L-arginine and L-citrulline as well as foods rich in nitrates such as beets and leafy greens) may inhibit viral replication cycles (e.g. SARS coronavirus)
  • Note that when used excessively, arginine can activate an unde lying herpes infection when intake of L-lysine is also low